Application of Optogenetics in Gene Therapy

Author(s): Toshihiro Kushibiki*, Miya Ishihara.

Journal Name: Current Gene Therapy

Volume 18 , Issue 1 , 2018

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Abstract:

The optogenetics approach uses a combination of genetic and optical methods to initiate and control functions in specific cells of biological tissues. Since the high-speed control of neuronal activity by irradiating channelrhodopsin-2 with blue light was reported in 2005, tremendous advancement and application of optogenetics in the field of neuroscience, such as in studies that associate neuronal activity with behaviors, have been initiated. Optogenetics is not only used as a research tool, but is also started to apply in the diagnosis of a disease or as therapy in various studies. Here, we summarize reports on therapy using a typical photoreceptor used in optogenetics, channelrhodopsin-2.

Keywords: Optogenetics, Channnelrhodopsin -2, Gene therapy, Neuroscience, Cardiac resynchronization, Insulin, diabetes.

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Article Details

VOLUME: 18
ISSUE: 1
Year: 2018
Page: [40 - 44]
Pages: 5
DOI: 10.2174/1566523218666180302163814
Price: $65

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