Background: Understanding of cervical cancer severity is still an important health issue across the world,
especially for developing countries. Cancer or abnormal growth of the cell is one of the major health problems of the
world. There are about two hundred types of malignancies reported till date. An updated statistic of all the main types
of cancer and pathophysiology of cervical cancer is a significant need for designing the future treatment strategy.
Objective: In this review, a brief update on cancer, its causes and different types has been discussed along with updated
statistics of patient's mortality. A brief overview of cervical cancer and its pathophysiology has been discussed
with special emphasis on its causative agent, human papilloma virus (HPV). A brief introduction and update on genetics,
molecular pathogenesis and prevalence of HPV and its role in cervical cancer have been added.
Conclusion: This review delivered an updated status of cervical cancer and provide novel therapeutic approaches for
targeting HPV. The detailed molecular and genomic information of the HPV help the researchers to develop more effective
and efficacious therapeutic strategies and preventive vaccines that will significantly contribute to the control and
anticipation of cervical cancer. Ultimately this may open new vistas to get rid of this deadly disease and may offer significant
reduction in the numbers of advanced cervical cancers and deaths from cervical cancer in the affected nations.