A Synopsis on the Role of Human Papilloma Virus Infection in Cervical Cancer

Author(s): Mohd Saeed*, Fawaz D. Alshammari, Md. Jahoor Alam, Khan Mohd Sarim, Khurshid Ahmad, Talib Hussain, Mahvish Khan, Mohammad Amjad Kamal, Mohd Adnan Kausar, Huda Mohammad Alkreathy, Syed Mohd Faisal, Ghulam Md. Ashraf*

Journal Name: Current Drug Metabolism

Volume 19 , Issue 9 , 2018

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Graphical Abstract:


Background: Understanding of cervical cancer severity is still an important health issue across the world, especially for developing countries. Cancer or abnormal growth of the cell is one of the major health problems of the world. There are about two hundred types of malignancies reported till date. An updated statistic of all the main types of cancer and pathophysiology of cervical cancer is a significant need for designing the future treatment strategy.

Objective: In this review, a brief update on cancer, its causes and different types has been discussed along with updated statistics of patient's mortality. A brief overview of cervical cancer and its pathophysiology has been discussed with special emphasis on its causative agent, human papilloma virus (HPV). A brief introduction and update on genetics, molecular pathogenesis and prevalence of HPV and its role in cervical cancer have been added.

Conclusion: This review delivered an updated status of cervical cancer and provide novel therapeutic approaches for targeting HPV. The detailed molecular and genomic information of the HPV help the researchers to develop more effective and efficacious therapeutic strategies and preventive vaccines that will significantly contribute to the control and anticipation of cervical cancer. Ultimately this may open new vistas to get rid of this deadly disease and may offer significant reduction in the numbers of advanced cervical cancers and deaths from cervical cancer in the affected nations.

Keywords: Cervical cancer, human papilloma virus, prevalence, tumor suppressor gene, immune system, HPV genome.

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Article Details

Year: 2018
Page: [798 - 805]
Pages: 8
DOI: 10.2174/1389200219666180302160317
Price: $65

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