Cholesterol Homeostasis and Liver X Receptor (LXR) in Atherosclerosis

Author(s): Shuyuan Guo, Luxiao Li, Huiyong Yin*

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets
Formerly Current Drug Targets - Cardiovascular & Hematological Disorders

Volume 18 , Issue 1 , 2018

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Graphical Abstract:


Cholesterol is an important lipid for maintaining cell membrane fluidity and generation of various hormones and bile acids. Thus, it is critical to maintain cholesterol homeostasis including absorption, trafficking, biosynthesis, and efflux; dysregulation of cholesterol homeostasis may lead to human disorders such as atherosclerosis. As a cholesterol sensor, nuclear receptor liver X receptor (LXR) is an important factor regulating cholesterol homeostasis. Extensive research has been carried out to examine the roles of LXR in atherosclerosis. In this review, we summarize our current understanding of the mechanisms how LXR regulates cholesterol synthesis, efflux, absorption, and conversion of cholesterol esters to cholesterol in the context of atherosclerosis. In addition, we also discuss the possibility of targeting LXR and cholesterol homeostasis as a potential interventional strategy for treating atherosclerosis.

Keywords: LXR, cholesterol, cholesterol ester, metabolism, atherosclerosis, CVD.

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Article Details

Year: 2018
Published on: 16 May, 2018
Page: [27 - 33]
Pages: 7
DOI: 10.2174/1871529X18666180302113713
Price: $65

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