Self-assembled fluorescent nanomaterials based on small-molecule organic dyes are gaining
increasing popularity in imaging and sensing applications over the past decade. This is primarily due to
their ability to combine spectral properties tunability and biocompatibility of small molecule organic
fluorophores with brightness, chemical and colloidal stability of inorganic materials. Such a unique
combination of features comes with rich versatility of dye-based nanomaterials: from aggregates of
small molecules to sophisticated core-shell nanoarchitectures involving hyperbranched polymers. Along
with the ongoing discovery of new materials and better ways of their synthesis, it is very important to
continue systematic studies of fundamental factors that regulate the key properties of fluorescent nanomaterials:
their size, polydispersity, colloidal stability, chemical stability, absorption and emission
maxima, biocompatibility, and interactions with biological interfaces. In this review, we focus on the
systematic description of various types of organic fluorescent nanomaterials, approaches to their synthesis,
and ways to optimize and control their characteristics. The discussion is built on examples from reports
on recent advances in the design and applications of such materials. Conclusions made from this
analysis allow a perspective on future development of fluorescent nanomaterials design for biomedical
and related applications.
Keywords: Organic fluorophores, molecular design, structure-property relationship, nanomaterial synthesis, colloidal
stability, spectral properties, supramolecular assembly, polymeric aggregates.
Klymchenko, A.S. Emerging Field of Self-Assembled Fluorescent Organic Dye Nanoparticles. J. Nanosci. Lett., 2013, 3(21), 1-8.
Ooyama, Y.; Sugino, M. EnoKi, T.; Yamamoto, K.; Tsunoji, N.; Ohshita, J. Aggregation-Induced Emission (AIE) Characteristic of Water-Soluble Tetraphenylethene (TPE). Bearing Four Sulfonate Salts. New J. Chem., 2017, 41, 4747-4749.
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