Nowadays, treatment with specific antivenins is considered the only cure for snakebites accidents.
However, access to antivenom obstructs the successful implementation of the World Health Organization international
guidelines. In the last few years, natural organic compounds, peptides, and proteins with the ability to
inhibit snake toxins and obtained from different sources such as plant extracts and animal blood have been proposed
as antivenoms. In this work, we will focus on the inhibitors of the main venom toxins, phospholipases A2
and metalloproteinases, and their application as novel antivenoms.
Keywords: Antivenom, protein, plant extracts, peptides, inhibition, metalloproteinases, phospholipase A2.
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