Natural Snake Venom Inhibitors and their Pharmaceutical Uses: Challenges and Possibilities

Author(s): Soledad Lorena Saavedra*, Lucia Avila, Silvana Laura Giudicessi, Fernando Albericio, Silvia Andrea Camperi, Osvaldo Cascone, Maria Camila Martinez-Ceron*

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 16 , 2018

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Nowadays, treatment with specific antivenins is considered the only cure for snakebites accidents. However, access to antivenom obstructs the successful implementation of the World Health Organization international guidelines. In the last few years, natural organic compounds, peptides, and proteins with the ability to inhibit snake toxins and obtained from different sources such as plant extracts and animal blood have been proposed as antivenoms. In this work, we will focus on the inhibitors of the main venom toxins, phospholipases A2 and metalloproteinases, and their application as novel antivenoms.

Keywords: Antivenom, protein, plant extracts, peptides, inhibition, metalloproteinases, phospholipase A2.

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Article Details

Year: 2018
Page: [1737 - 1747]
Pages: 11
DOI: 10.2174/1381612824666180223172854
Price: $65

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PDF: 36