Background: Several SNPs were identified through GWAS for their
association with type 2 diabetes which has implications to pancreatic β-cell physiology.
Objective: We aimed to study the role of risk alleles of TCF7L2, KCNJ11, CDKN2A,
CDKAL1, IGF2BP2, SLC30A8 and KCNQ1 along with pharmacokinetic variants in
response to sulfonylureas.
Method: We performed a prospective study on 209 newly diagnosed subjects; treatment
naive T2D subjects were recruited. Individuals were started with glibenclamide
monotherapy and followed-up for 12 weeks. Genotyping was done, using PCR-RFLP
and TETRA-ARMS PCR and confirmed by DNA sequencing.
Results: In univariate regression analysis, KCNJ11 (rs5219) was only the predictor for
glibenclamide treatment failure.
Conclusion: The present data suggests a possible role of KCNJ11 gene in altered
response to glibenclamide.