Progress in the Synthesis and Modification on Ginsenosides

Author(s): Li Huang, Cheng Zou*, Yunhuan Liu, Rui Li, Wenyue Duan, Runan Du, Weimin Yang*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 15 , Issue 6 , 2018

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Graphical Abstract:


Ginsenosides present various application in many areas, however, considering that the preparation of natural ginsenosides is comparatively in straitened circumstances, and not conducive to industrial production; the chemosynthesis and structural modification on natural ginsenosides with high yield and ready availability are significant in the discovery of new active ingredients and industrialization. Therefore, restriction on the achievement of ginsenosides from plants can be possibly solved by the method; moreover, derivatives of ginsenosides are be applied to the study of structure-activity relationship, thereby being beneficial to the development of new drugs. This paper reviews recent progress of the synthesis and structural modification for different types of ginsenosides, especially showing solicitude for damaran-type ginsenosides, which contain diverse ways of synthesis and modification (such as esterification, alkylation, sulfation, oxidation and catalytic hydrogenation). The prospect of ginsenosides in chemistry is evaluated synchronously.

Keywords: Ginsenoside, saponins, chemosynthesis, modification, antitumor, configuration.

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Article Details

Year: 2018
Published on: 03 October, 2018
Page: [444 - 458]
Pages: 15
DOI: 10.2174/1570193X15666180221151524
Price: $65

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