Ginsenosides present various application in many areas, however, considering that the preparation
of natural ginsenosides is comparatively in straitened circumstances, and not conducive to industrial
production; the chemosynthesis and structural modification on natural ginsenosides with high yield
and ready availability are significant in the discovery of new active ingredients and industrialization.
Therefore, restriction on the achievement of ginsenosides from plants can be possibly solved by the
method; moreover, derivatives of ginsenosides are be applied to the study of structure-activity relationship,
thereby being beneficial to the development of new drugs. This paper reviews recent progress of
the synthesis and structural modification for different types of ginsenosides, especially showing solicitude
for damaran-type ginsenosides, which contain diverse ways of synthesis and modification (such as
esterification, alkylation, sulfation, oxidation and catalytic hydrogenation). The prospect of ginsenosides
in chemistry is evaluated synchronously.