Title:Bis-coumarin Derivatives and Their Biological Activities
VOLUME: 18 ISSUE: 2
Author(s):Qing-Cheng Ren, Chuan Gao, Zhi Xu, Lian-Shun Feng, Ming-Liang Liu*, Xiang Wu* and Feng Zhao*
Affiliation:WuXi AppTec (Wuhan), Hubei, WuXi AppTec (Wuhan), Hubei, WuXi AppTec (Wuhan), Hubei, WuXi AppTec (Wuhan), Hubei, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, Hubei, WuXi AppTec (Wuhan), Hubei, WuXi AppTec (Wuhan), Hubei
Keywords:Bis-coumarin, anti-bacterial, antitumor, antiviral, hybrid compounds, structure-activity relationships.
Abstract:Bis-coumarins have caused great interests in the recent years. These compounds exhibit
diverse biological activities which are ascribed to their ability to exert noncovalent interactions with
the various active sites in organisms. Some of them such as dicoumarolum and dicoumarol were approved
for therapeutic purposes in clinical practice. Encouraged by the above facts, numerous biscoumarin
derivatives have been synthesized and screened for their biological activities, and many of
them showed promising potency. This review is focused on the biological potential of bis-coumarin
derivatives with particular mention of those exhibiting antibacterial, anticoagulant, antiinflammatory,
antiviral, anti-parasite and antitumor activities, and their structure-activity relationships
are also discussed.
