Background: This review presents the exhaustive exploration of 1,3,5-triazine scaffold
for development of analogs of anticancer drugs, over the last century. In the recent years, striazine
moiety has been one of the most studied moiety, showing broad-spectrum pharmacological
activities such as antibacterial, antifungal, analgesic, anti-HIV, antileishmanial, antitrypanosomal,
antimalarial and antiviral. Nowadays, many boffins are have become interested in novel
synthesis of s-triazine derivatives because of low cost and ease of availability.
Methods: This scaffold has been extensively investigated mainly in the past decade. Many products
have been synthesized from different starting materials and these synthetic products possess
anticancer potential against various cell lines.
Results: Many 1,3,5-triazine analogs exhibited significant anticancer activity in various models
and cell lines exhibiting different mechanisms. Some analogs have also shown good pharmacokinetic
parameters with less IC50 values.
Conclusion: Various 1,3,5-triazine analogs have shown potent activities and may be regarded as
clinical candidates for future anticancer formulations. This review may be helpful to those researchers
seeking required information with regard to the drug design and medicinal properties of
1,3,5-triazine derivatives for selected targets. This review may also offer help to find and improve
clinically viable anticancer molecules.