Abstract
The control of Tuberculosis (TB) is becoming more challenging due to drug resistance. Therefore, there is a dire need for newer drugs to tackle the nuances of resistant strains. Many molecular scaffolds are in the pipeline against TB. Among them, carbazole has a distinct advantage over other scaffolds because of its various sources i.e. medicinal plants, coal tar, and synthesis, besides the excellent antitubercular efficacy. This review provides an overview of carbazole alkaloids and their synthetic derivatives reported against Mycobacterium tuberculosis H37Rv (Mtb). The structure-activity relationship is also established to understand the molecular requirements for design and development of more potent antitubercular drugs.
Keywords: Alkaloids, carbazole, resistance, SAR, tuberculosis, antitubercular drugs.
Mini-Reviews in Organic Chemistry
Title:Carbazole: A Potent Scaffold for Antitubercular Drugs
Volume: 15 Issue: 6
Author(s): Satheeshkumar Sellamuthu, Gopichand Gutti, Devendra Kumar and Sushil Kumar Singh*
Affiliation:
- Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi-221005,India
Keywords: Alkaloids, carbazole, resistance, SAR, tuberculosis, antitubercular drugs.
Abstract: The control of Tuberculosis (TB) is becoming more challenging due to drug resistance. Therefore, there is a dire need for newer drugs to tackle the nuances of resistant strains. Many molecular scaffolds are in the pipeline against TB. Among them, carbazole has a distinct advantage over other scaffolds because of its various sources i.e. medicinal plants, coal tar, and synthesis, besides the excellent antitubercular efficacy. This review provides an overview of carbazole alkaloids and their synthetic derivatives reported against Mycobacterium tuberculosis H37Rv (Mtb). The structure-activity relationship is also established to understand the molecular requirements for design and development of more potent antitubercular drugs.
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Cite this article as:
Sellamuthu Satheeshkumar , Gutti Gopichand , Kumar Devendra and Kumar Singh Sushil *, Carbazole: A Potent Scaffold for Antitubercular Drugs, Mini-Reviews in Organic Chemistry 2018; 15 (6) . https://dx.doi.org/10.2174/1570193X15666180220141342
DOI https://dx.doi.org/10.2174/1570193X15666180220141342 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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