Background: Autoimmune disease is a refractory disease. Accumulating Evidence has revealed
that the manipulation of mesenchymal stem cells may have the potential to control or even treat
autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a
new line of mesenchymal stem cells that have displayed some potential advantages in controlling and
treating autoimmune diseases.
Objective: In this review, we briefly update the current understanding on the biology of GMSCs and
their effects on preventing and treating autoimmune diseases.
Conclusion: The availability of gingival mesenchymal stem cells (GMSCs), together with their potent
capacity of multi-directional differentiation and inflammatory modulation, making GMSCs an ideal
subtype of MSCs in treating autoimmune disease. Our and other studies have launched the earliest
appraisal on GMSCs and carried out a lot of biological researches. The clinical trial of GMSCs on patients
with autoimmune diseases will further approve their therapeutic effects, as well as its cellular and