Title:Chalcones and Chromones in Copper-Catalyzed Azide–Alkyne Cycloadditions (CuAAC)
VOLUME: 22 ISSUE: 13
Author(s):Sara M. Tome, Augusto C. Tome*, Raquel G. Soengas and Artur M.S. Silva*
Affiliation:Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Organic Chemistry Sector, University of Almeria, Carretera de Sacramento s/n, 04120 Almeria, Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro
Keywords:Chalcone, chromone, flavone, isoflavone, triazole, 1, 3-dipolar cycloaddition, click chemistry.
Abstract:Click chemistry has emerged as a valuable synthetic tool for the assembly of diverse molecular
units. In particular, the copper-catalyzed azide–alkyne cycloadditions (CuAAC) revealed to be extremely versatile
and are currently used for the synthesis of molecules with a wide range of applications. Accordingly,
CuAAC reactions have been extensively used for the functionalization of phenolic compounds, many of them
with well-known biological properties. Herein, an overview of the most important advances in the application
of CuAAC reactions to chalcones and chromones, including flavones, since 2002 is presented. In particular,
this review discusses the use of azidochalcones, azidochromones, alkynylchalcones and alkynylchromones in
1,3-dipolar cycloadditions. The biological properties of some of the resulting conjugates, where the two units
are linked by a 1,2,3-triazole bridge, are also presented. In some reported examples, the new conjugates revealed
additive activities which represent a promising step forward in medicinal chemistry.
