Background & Objective: The large conductance calcium-activated potassium (BK) channel,
extensively distributed in the central nervous system (CNS), is considered as a vital player in the
pathogenesis of epilepsy, with evidence implicating derangement of K+ as well as regulating action
potential shape and duration. However, unlike other channels implicated in epilepsy whose function in
neurons could clearly be labeled “excitatory” or “inhibitory”, the unique physiological behavior of the
BK channel allows it to both augment and decrease the excitability of neurons. Thus, the role of BK in
epilepsy is controversial so far, and a growing area of intense investigation.
Conclusion: Here, this review aims to highlight recent discoveries on the dichotomous role of BK
channels in epilepsy, focusing on relevant BK-dependent pro- as well as antiepileptic pathways, and
discuss the potential of BK specific modulators for the treatment of epilepsy.