Background and Objective: Metabolic syndrome (MS) is widespread among middle age
people and presents an acute issue in preventive cardiology. A list of conditions associated with MS is
quite long and it is constantly growing. Despite the data, described in scientific literature, on general
pathogenetic mechanisms, the conditions associated with androgynous status, are not included into the
register of MS associated nosologies. Such association is identified in men older than 60 years old and
is explained by age related hypoandrogenaemia. However, the issue of occurrence rate of lower urinary
tract syndromes (LUTS) in young men with MS and their association of androgen levels remains open.
Methods: 62 European men aged from 25 to 40 (30 patients with MS and 32 conditionally healthy
persons) were examined. Apart from generally accepted methods of physical and instrumental examination,
evaluation of hormonal status (insulin, testosterone, dehydrotestosteron), IPSS-QOI testing and
transrectal USI of prostate and bladder were performed.
Results: Revealed a high frequency of increasing the size and volume of the prostate gland, the number
of points on the IPSS questionnaire, corresponding to the initial manifestation of hyperplastic prostate
diseases on the background of insulin resistance and normal androgen levels raises questions about the
search for new pathogenetic links of the metabolic syndrome with the processes of induction of prostate
Conclusion: Modern standards of examination of patients with MS do not include routine methods for
the detection of prostate diseases. The above data raise questions about the need for further study in
young patients with verified MS, including IPSS-QOI questionnaire surveying and TRUS.