Background: Common auto-inflammatory disorders (CAIDs) constitute a wide array of
ailments ranging from acute allergies to chronic conditions. Globally, CAIDs remain one of the
leading causes of disability and morbidity. Despite playing a leading therapeutic role, the vast
profusion of anti-inflammatory synthetic agents have not been able to fully resolve a panoply of
CAIDs. Additionally, contemporary synthetic therapy approaches remain bounded by a wide array of
limitations essentially being adverse effects and unaffordable costs. In this advent, the use of herbal
products provides an interesting avenue to explore in view of developing such treatment regimens.
Objective: This review article endeavors to highlight potential herbal products and isolated
phytochemicals which can be of benefit in the prophylaxis, management, and treatment alongside
avoiding the relapse of CAIDs.
Conclusion: This review article has highlighted that herbals, herbal products, and isolated
metabolites hold a huge potential in the prophylaxis, management, and treatment of CAIDs. Herbals
can act on various targets involved in the pathogenesis of inflammatory disorders. In addition, novel
approaches for the management of CAIDs are numerous. Indeed, nanoparticles loaded with
phytochemicals have been developed to specifically target the colon for IBD treatment. In silico
approaches using herbals also offer unlimited avenues to decipher new pharmacophores.
Investigating the potential of polyherbal formulations is another unique approach which can be
investigated. Given the inefficacy of conventional medicines, the concomitant use of conventional
and herbal medicines can also be explored.