Methacholin Provocation Test in COPD and Healthy Smokers

Author(s): Alfian Nur Rosyid*, Daniel Maranatha

Journal Name: Current Respiratory Medicine Reviews

Volume 13 , Issue 3 , 2017

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Graphical Abstract:


Objective: Chronic Obstructive Pulmonary Disease (COPD) has become a global health concern. The data indicate that only 20-25% of smokers develop COPD. The prevalence of bronchial hyperresponsiveness (BHR) among smokers that develop into COPD is presumed higher than smokers who do not develop COPD.

Methods: Samples from lung clinics in three government hospitals in Surabaya were examined. The samples had to meet the inclusion criteria and were willing to participate in the research. The samples were divided into two groups: COPD (group A and group B) and healthy smokers. Samples with asthma, allergies, Asthma COPD Overlap Syndrome (ACOS), tuberculosis, post-tuberculosis, Forced Expiratory Volume in 1 second (FEV1) <50% predicted, FEV1 <1 liter, exacerbation ≥1 times that need hospital admission in a previous year were excluded from the study. The values of Provocation Concentration causing fall of 20% in FEV1 (PC20) with Methacholine Challenge Test on both groups samples were evaluated, the average was assessed and differences were compared.

Results: There were 182 samples and only 23 samples were analyzed from each group; COPD and healthy smokers. BHR in COPD group were 47.83%, higher than healthy smoker (16 vs. 7) with significance PC20 average (3.77±3.74 vs. 10.20±3.73) mg.mL-1, p = 0.001. An analysis on BHR on COPD group indicated that group B had more BHR compared to group A (73.3% vs. 62.5%) with an average (3.55±2.96 vs. 4.26±5.49) mg.mL-1, but no statistically significant difference (p = 0.738).

Conclusion: There were samples with more BHR in COPD group compared to healthy smokers. Smokers with BHR were at a risk of getting COPD.

Keywords: Bronchial hyperresponsiveness, cigarettes, COPD, exacerbation, lungs, methacholine challenge test.

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Article Details

Year: 2017
Published on: 27 March, 2018
Page: [168 - 174]
Pages: 7
DOI: 10.2174/1573398X14666180213092735
Price: $65

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