Direct and Facile Synthesis of Primary Amides from Carboxylic Acids via Acyl Isocyanate Intermediates Using Mukaiyama Reagent

Title:Direct and Facile Synthesis of Primary Amides from Carboxylic Acids via Acyl Isocyanate Intermediates Using Mukaiyama Reagent

VOLUME: 15 ISSUE: 9

Author(s):Roya Azadi* and Zahra Motamedpoor

Affiliation:Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz

Keywords:2-Chloro-1-methylpyridinium iodide, acyl isocyanate, amide, carboxylic acid, mukaiyama reagent.

Abstract:A very simple and efficient procedure for the preparation of primary amides is described from carboxylic acids using Mukaiyama reagent/KNCO in aqueous acetonitrile. Availability of the reagents, simplicity, and easy workup of the reaction crude make this method attractive for organic chemists.

Cite this article as:

Roya Azadi* and Zahra Motamedpoor, “Direct and Facile Synthesis of Primary Amides from Carboxylic Acids via Acyl Isocyanate Intermediates Using Mukaiyama Reagent”, Letters in Organic Chemistry (2018) 15: 801. https://doi.org/10.2174/1570178615666180212152643

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