Title:Direct and Facile Synthesis of Primary Amides from Carboxylic Acids via Acyl Isocyanate Intermediates Using Mukaiyama Reagent
VOLUME: 15 ISSUE: 9
Author(s):Roya Azadi* and Zahra Motamedpoor
Affiliation:Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz
Keywords:2-Chloro-1-methylpyridinium iodide, acyl isocyanate, amide, carboxylic acid, mukaiyama reagent.
Abstract:A very simple and efficient procedure for the preparation of primary amides is described
from carboxylic acids using Mukaiyama reagent/KNCO in aqueous acetonitrile. Availability of the
reagents, simplicity, and easy workup of the reaction crude make this method attractive for organic
chemists.