Background: Sodium-glucose co-transporters 2 inhibitors have emerged as a novel antidiabetic
class of drugs offering significant ameliorating effects on a variety of cardiovascular risk
factors, secondary to their mechanism of action, including blood pressure and body weight.
Objective: The purpose of this article is to discuss available data on the impact of SGLT-2
inhibitors on blood pressure and body weight compared with other available anti-diabetic drugs and
to present potential mechanisms mediating these effects.
Methods: A comprehensive review of the literature was performed to identify studies examining the
effects of SGLT-2 inhibitors on blood pressure and body weight.
Results: SGLT-2 inhibition has been related with a mild decrease in blood pressure of
approximately 3-5mmHg in systolic and 1-2mmHg in diastolic blood pressure. These data have
been confirmed with 24h ambulatory measurements, as well. Furthermore, given the loss of calories
in the urine, a mild decrease in body weight is anticipated, as well. Studies with this class of drugs
noted a reduction in body weight of 2 to 3 kg, similar to the loss noted with the use of glucagon-like
peptide 1 analogues, the only class of drugs that has offered significant reductions in body weight
Consclusion: The beneficial effects of the SGLT-2 inhibition on an abundance of cardiovascular
risk factors, including blood pressure and body weight, have created great expectations for potential
benefits from the cardiovascular events standpoint, a theory that was confirmed in the two available
cardiovascular studies of this promising class of drugs.