Genetic Mechanisms of Antibiotic Resistance and the Role of Antibiotic Adjuvants

Author(s): Daniela Santos Pontes, Rodrigo Santos Aquino de Araujo, Natalina Dantas, Luciana Scotti, Marcus Tullius Scotti, Ricardo Olimpio de Moura, Francisco Jaime Bezerra Mendonca-Junior*

Journal Name: Current Topics in Medicinal Chemistry

Volume 18 , Issue 1 , 2018

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Graphical Abstract:


The ever increasing number of multidrug-resistant microorganism pathogens has become a great and global public health threat. Antibiotic mechanisms of action and the opposing mechanisms of resistance are intimately associated, but comprehension of the biochemical and molecular functions of such drugs is not a simple exercise. Both the environment, and genetic settings contribute to alterations in phenotypic resistance (natural bacterial evolution), and make it difficult to control the emergence and impacts of antibiotic resistance. Under such circumstances, comprehension of how bacteria develop and/or acquire antibiotic resistance genes (ARG) has a critical role in developing propositions to fight against these superbugs, and to search for new drugs. In this review, we present and discuss both general information and examples of common genetic and molecular mechanisms related to antibiotic resistance, as well as how the expression and interactions of ARGs are important to drug resistance. At the same time, we focus on the recent achievements in the search for antibiotic adjuvants, which help combat antibiotic resistance through deactivation of bacterial mechanisms of action such as β-lactamases. Recent advances involving the use of anti-resistance drugs such as: efflux pump inhibitors; anti-virulence drugs; drugs against quorum sensing; and against type II/III secretion systems are revealed. Such antibiotic adjuvants (as explored herein) collaborate against the problems of antibiotic resistance, and may restore or prolong the therapeutic activity of known antibiotics.

Keywords: Antibiotic resistance genes, Horizontal genetic transfers, Resistance-nodulation-division, Multidrug-resistant microorganism, β-lactamases, Anti-resistance drugs.

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Article Details

Year: 2018
Page: [42 - 74]
Pages: 33
DOI: 10.2174/1568026618666180206095224
Price: $65

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