Background & Objective: Increased level of reactive oxygen species is a hallmark of common
neurodegenerative diseases such as Alzheimer’s Disease and Parkinson’s Disease. ROS can oxidize
macromolecules including DNA, lipids and proteins and cause oxidative damage to the cell.
Emerging evidence indicate that potassium channels in the central nervous system are no exceptions to
these oxidative modifications.
Conclusion: In this mini-review, we summarized recent reports on the oxidation of potassium channels
in the CNS and the consequently resulted changes in cell functions and viability, with focus on its
implications in neurodegenerative diseases.
Keywords: Aging, neurodegenerative diseases, oxidation, potassium channel, reactive oxygen species (ROS), lipids and proteins.
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