Oxidation of Potassium Channels in Neurodegenerative Diseases: A Mini- Review

Author(s): Junsheng Yang*, Xueni Yan

Journal Name: CNS & Neurological Disorders - Drug Targets
(Formerly Current Drug Targets - CNS & Neurological Disorders)

Volume 17 , Issue 4 , 2018

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Graphical Abstract:


Background & Objective: Increased level of reactive oxygen species is a hallmark of common neurodegenerative diseases such as Alzheimer’s Disease and Parkinson’s Disease. ROS can oxidize macromolecules including DNA, lipids and proteins and cause oxidative damage to the cell. Emerging evidence indicate that potassium channels in the central nervous system are no exceptions to these oxidative modifications.

Conclusion: In this mini-review, we summarized recent reports on the oxidation of potassium channels in the CNS and the consequently resulted changes in cell functions and viability, with focus on its implications in neurodegenerative diseases.

Keywords: Aging, neurodegenerative diseases, oxidation, potassium channel, reactive oxygen species (ROS), lipids and proteins.

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Article Details

Year: 2018
Page: [267 - 271]
Pages: 5
DOI: 10.2174/1871527317666180202110056
Price: $65

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PDF: 35