Title:PPARγ-targeting Potential for Radioprotection
VOLUME: 19 ISSUE: 15
Author(s):Simran Kaur, Alo Nag, Ajay Kumar Singh and Kulbhushan Sharma*
Affiliation:Institute of Nuclear Medicine and Allied Sciences, Lucknow Road, Timarpur, Delhi-110054, New Delhi, Department of Biochemistry, University of Delhi South Campus, Benito Juarez Road, Dhaula Kuan, New Delhi- 110021, New Delhi, Institute of Nuclear Medicine and Allied Sciences, Lucknow Road, Timarpur, Delhi-110054, New Delhi, Institute of Nuclear Medicine and Allied Sciences, Lucknow Road, Timarpur, Delhi-110054, New Delhi
Keywords:PPARγ, oxidative stress, radiation, cancer, NFkappaB, inflammation.
Abstract:Background: Peroxisomal proliferator receptor gamma (PPARγ) is a class of nuclear hormone
receptor family involved in insulin sensitization. In addition, PPARγ has a key role in the protection
against oxidative stress and inflammation through regulation of NFkappaB levels and crosstalk
with the Nrf2 pathway. Also, its role in the modulation of immune response is substantial.
Objective: Radiation-induced oxidative stress is the sole determinant of damage to hematopoietic, gastrointestinal
system and immune system suppression. Uncontrolled exposure to normal cells during
radiotherapy raises the demand for novel and efficient radioprotectors. In this review, we will present
an overview of the involvement of PPARγ in radiation-induced damage and inflammation with major
emphasis on whether PPARγ can serve as a suitable radiomodification target.
Conclusion: Through this review, we have justified that PPARγ having both radioprotective as wells
as radiotherapeutic potential, may serve as an attractive target for the development of novel and more
effective therapies.
