Background and Objective: The adipose tissue has been recognized as an important endocrine
organ, which is metabolically active and expresses and secretes various inflammatory cytokines.
Inflammation is involved in obesity-related complications. As such, the present study investigated the
correlation between biochemical parameters, serum proinflammatory cytokines and adipokines in individuals
Methods: Based on the body mass index (BMI), 30 subjects were divided into 3 groups: eutrophic (GC,
n = 10), overweight (GOW, n = 10) and obese (GOB, n = 10). Serum glucose, cholesterol (total-C, HDLC
and LDL-C), triglycerides, total proteins, uric acid and insulin were determined, as well as cytokines
IL-8, TNF-α, IL-1β, and IL-6, leptin and adiponectin.
Results: GOB showed the highest glucose, total and LDL-C, triglycerides, uric acid, insulin, leptin, IL-
8, IL-1β, IL-6, TNF-α and lowest adiponectin levels. In general, adiponectin exhibited an inverse correlation
with BMI, abdominal circumference, LDL-C, IL-6, TNF-α, leptin and leptin-adiponectin ratio
(LAR) and a positive correlation with HDL-C. Leptin was positively correlated with BMI, abdominal
circumference, insulin, IL-6, TNF-α and LAR and negatively correlated with HDL-C and adiponectin.
The LAR was positively correlated with BMI, waist circumference, insulin, TNF-α and negatively
associated with HDL-C.
Conclusion: The results confirm that obesity changes the lipid and glycemic profiles of individuals,
increases the proinflammatory adipokine levels and reduces those of anti-inflammatory adipokines,
promoting a state of chronic inflammation.