Practical and Efficient Synthesis of Hydroxyaryl Ketones Catalyzed by HF@SiO2 under Solvent-free Condition

Author(s): Hossein Paghandeh, Hamid Saeidian*, Mohammad Ghaffarzadeh

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 9 , 2018


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Abstract:

A wide variety of hydroxyaryl ketones bearing different motifs was successfully synthesized with good yields and excellent selectivities in the presence of HF@SiO2 as an environmental friendly acid under solvent-free condition. Mild and green reaction conditions and excellent yields (50-91%) make this method an attractive method for the efficient synthesis of hydroxyaryl ketones. Fries rearrangement of phenyl benzoate in the presence of HF@SiO2 led to p-hydroxybenzophenone, while phenyl acetate in the same conditions produced o-hydroxyacetophenone as a single isomer.

Keywords: Fries rearrangement, hydroxyaryl ketones, HF@SiO2, solvent-free condition, selective synthesis, isomer.

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Article Details

VOLUME: 15
ISSUE: 9
Year: 2018
Published on: 26 July, 2018
Page: [809 - 814]
Pages: 6
DOI: 10.2174/1570178615666180126153924
Price: $65

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