Objective: The aim of the present work is to prepare Mefenamic acid nanoparticles
by Nanoprecipitation technique. Two different polymers were used namely Ethyl
cellulose and Eudragit S-100 to study the effect of polymers on the release rate of the
prepared formulation. The process parameters such as stirring rate, %surfactant (w/v),
drug to polymer ratio and so forth were optimized.
Methods: Nanoprecipitation technique was employed in which drug and polymer were
dissolved in an organic solvent and added drop wise to 0.4% (w/v) Poly Vinyl Alcohol
aqueous solution under continuous magnetic stirring. After 5hrs, the solvent was removed
by means of rotary evaporator to collect amorphous nanoparticles. For each polymer, total
five formulations were prepared by varying the concentration of drug and polymer.
Results: The prepared nanoparticles were then characterized for drug-polymer interaction
study, mean particle diameter, stability, and surface morphology and evaluated for drug
content, entrapment efficiency, loading capacity, and in-vitro drug release. After evaluating
the parameters the best formulation was found to be F3 formulation of ethyl cellulose
with drug content of 94%, drug entrapment efficiency of 92.2%, loading capacity of
32.6%, mean particle diameter of 132.8nm and zeta potential value of -42.8mV. FTIR
spectrum revealed no drug-polymer interaction and in-vitro drug release data showed
90.22% of drug release sustained up to 12hrs.
Conclusion: Ethyl cellulose was found to be the better polymer for the preparation of Mefenamic
acid nanoparticles by Nanoprecipitation technique. Because of the mean particle
diameter, excellent stability, higher drug entrapment efficiency and drug loading capacity.