Correlation Between White Blood Cell Count and Insulin Resistance in Type 2 Diabetes

Author(s): Armin Mahdiani, Masoume Kheirandish, Shokoufeh Bonakdaran*

Journal Name: Current Diabetes Reviews

Volume 15 , Issue 1 , 2019

Become EABM
Become Reviewer
Call for Editor


Background: The role of chronic inflammation in insulin resistance states and the pathogenesis of metabolic syndrome, cardiovascular disease and diabetes have been reported earlier. White Blood Cell (WBC) count is an easy marker for estimation of systemic inflammation.

Objective: This study is to clarify whether WBC count is associated with insulin resistance in type 2 diabetic patients.

Methods: This cross sectional study was conducted in 283 patients with type 2 diabetes and in 283 healthy non diabetic subjects as control group. Data including: age, gender, blood pressure, height and weight, history of smoking were collected for each patient. Fasting blood sugar, HbA1C, insulin, lipid profiles, creatinine, Urine albumin to creatinine ratio, high sensitive C- reactive protein (HCRP) and WBC was measured for all patients. WBC count was measured in control group. Two groups were compared in WBC count. Insulin resistance was calculated with HOMA-IR formula. Association of WBC count with insulin resistance and metabolic parameters was assessed in diabetic patients.

Results: WBC count was significantly associated with body mass index, hypertension, and triglyceride level. There was not significant association between WBC count and glycemic index and insulin resistance.

Conclusion: An elevated WBC count (even in the normal range) is closely related to various components of metabolic syndrome but not related to insulin resistance in type 2 diabetes.

Keywords: Diabetes, insulin resistance, WBC, inflammation, metabolic syndrome, obesity.

Rathmann W, Giani G. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27(10): 2568-9.
Harati H, Hadaegh F, Saadat N, Azizi F. Population-based incidence of Type 2 diabetes and its associated risk factors: results from a six-year cohort study in Iran. BMC Public Health 2009; 9(1): 186.
Ohshita K, Yamane K, Hanafusa M, et al. Elevated white blood cell count in subjects with impaired glucose tolerance. Diabetes Care 2004; 27(2): 491-6.
Nakanishi N, Yoshida H, Matsuo Y, Suzuki K, Tatara K. White blood-cell count and the risk of impaired fasting glucose or Type II diabetes in middle-aged Japanese men. Diabetologia 2002; 45(1): 42-8.
Maleki A, Rashidi N, Meybodi HA, et al. Metabolic syndrome and inflammatory biomarkers in adults: A population-based survey in Western region of Iran. ICRJ 2014; 8(4): 156.
Sefil F, Ulutas KT, Dokuyucu R, et al. Investigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus. J Int Med Res 2014; 42(2): 581-8.
Karthikeyan V, Lip G. White blood cell count and hypertension. J Hum Hypertens 2006; 20(5): 310-2.
Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 352(16): 1685-95.
Tohidi M, Ghasemi A, Hadaegh F, Derakhshan A, Chary A, Azizi F. Age-and sex-specific reference values for fasting serum insulin levels and insulin resistance/sensitivity indices in healthy Iranian adults: Tehran lipid and glucose study. Clin Biochem 2014; 47(6): 432-8.
Karakasilioti I, Kamileri I, Chatzinikolaou G, et al. DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria. Cell Metab 2013; 18(3): 403-15.
Spoto B, Di Betta E, Mattace-Raso F, et al. Pro-and anti-inflammatory cytokine gene expression in subcutaneous and visceral fat in severe obesity. Nutr Metab Cardiovasc Dis 2014; 24(10): 1137-43.
McLaughlin T, Deng A, Gonzales O, et al. Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women. Diabetologia 2008; 51(12): 2303-8.
Recasens M, Ricart W, Fernández-Real J. Obesity and inflammation. Revista de medicina de la Universidad de Navarra 2003; 48(2): 49-54.
Lubrano V, Venturi E, Balzan S, Baldi S, Natali A, Eds. Impact of risk factor for atherosclerosis on microvascular endothelial function: An in vitro study. Theoretical biology forum;. 2015.
Furuncuoğlu Y, Tulgar S, Dogan A, Cakar S, Tulgar Y, Cakiroglu B. How obesity affects the neutrophil/lymphocyte and platelet/lymphocyte ratio, systemic immune-inflammatory index and platelet indices: A retrospective study. Eur Rev Med Pharmacol Sci 2016; 20(7): 1300-6.
Vargas R, Ryder E, Diez-Ewald M, et al. Increased C-reactive protein and decreased Interleukin-2 content in serum from obese individuals with or without insulin resistance: Associations with leukocyte count and insulin and adiponectin content. Diabetes Metab Syndr 2016; 10(1): S34-41.
Bastard J-P, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006; 17(1): 4-12.
Pusuroglu H, Akgul O, Erturk M, et al. A comparative analysis of leukocyte and leukocyte subtype counts among isolated systolic hypertensive, systo-diastolic hypertensive, and non-hypertensive patients. Kardiol Pol 2014; 72(8): 748-54.
Schillaci G, Pirro M, Pucci G, et al. Prognostic value of elevated white blood cell count in hypertension. Am J Hypertens 2007; 20(4): 364-9.
Babio N, Ibarrola-Jurado N, Bulló M, et al. White blood cell counts as risk markers of developing metabolic syndrome and its components in the PREDIMED study. PLoS One 2013; 8(3): e58354.
Lohsoonthorn V, Dhanamun B, Williams MA. Prevalence of metabolic syndrome and its relationship to white blood cell count in a population of Thai men and women receiving routine health examinations. Am J Hypertens 2006; 19(4): 339-45.
Khovidhunkit W, , Memon RA,, Feingold KR, Grunfeld C,. Infection¶ and inflammation-induced proatherogenic changes of lipoproteins. J Infect Dis 2000; 181(Supplement_3): : S462-72.
Jonkers IJ, Mohrschladt MF, Westendorp RG, van der Laarse A, Smelt AH. Severe hypertriglyceridemia with insulin resistance is associated with systemic inflammation: reversal with bezafibrate therapy in a randomized controlled trial. Am J Med 2002; 112(4): 275-80.
Jiang H, Yan W-H, Li C-J, Wang A-P, Dou J-T, Mu Y-M. Elevated white blood cell count is associated with higher risk of glucose metabolism disorders in middle-aged and elderly Chinese people. Int J Environ Res Public Health 2014; 11(5): 5497-509.
Hanley AJ, Retnakaran R, Qi Y, et al. Association of hematological parameters with insulin resistance and β-cell dysfunction in nondiabetic subjects. J Clin Endocrinol Metab 2009; 94(10): 3824-32.
Moradi S, Kerman SRJ, Rohani F, Salari F. Association between diabetes complications and leukocyte counts in Iranian patients. Int J Inflamm 2012; 5: 7.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2019
Published on: 19 January, 2018
Page: [62 - 66]
Pages: 5
DOI: 10.2174/1573399814666180119143026
Price: $65

Article Metrics

PDF: 40
PRC: 1