Gene therapy has been receiving widespread attention due to its unique advantage in regulating
the expression of specific target genes. In the field of cancer gene therapy, modulation of gene
expression has been shown to decrease oncogenic factors in cancer cells or increase immune responses
against cancer. Due to the macromolecular size and highly negative physicochemical features of plasmid
DNA, efficient delivery systems are an essential ingredient for successful gene therapy. To date, a
variety of nanostructures and materials have been studied as nonviral gene delivery systems. In this
review, we will cover nonviral delivery strategies for cancer gene therapy, with a focus on target cancer
genes and delivery materials. Moreover, we will address current challenges and perspectives for
nonviral delivery-based cancer gene therapeutics.
Keywords: Cancer gene therapy, Nonviral gene therapy, Nonviral delivery, Target cancer gene, Macromolecular, DNA.
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