Title:Mechanical Support in Cardiogenic Shock Complicating Acute Coronary Syndrome: Ready for Prime Time?
VOLUME: 16 ISSUE: 5
Author(s):Guillaume Schurtz, Marc Laine, Clement Delmas, Francois Kerbaul, Etienne Puymirat, Gilles Lemesle and Laurent Bonello*
Affiliation:Universite de Lille, Inserm, CHU Lille, Institut Pasteur, U1011, Lille, Assistance Publique Hopitaux de Marseille, Department of Cardiology, Hopital Nord, Mediterranean Academic Association for Research and Studies in Cardiology (MARS Cardio), Aix-Marseille University, INSERM UMRS 1076, Marseille, Intensive Cardiac Care Unit Rangueil University Hospital, Toulouse, Pole RUSH, Assistance Publique Hopitaux de Marseille, Marseille, Departement de Cardiologie, Hopital Europeen Georges Pompidou, Assistance Publique des Hopitaux de Paris, Paris, Universite de Lille, Inserm, CHU Lille, Institut Pasteur, U1011, Lille, Assistance Publique Hopitaux de Marseille, Department of Cardiology, Hopital Nord, Mediterranean Academic Association for Research and Studies in Cardiology (MARS Cardio), Aix-Marseille University, INSERM UMRS 1076, Marseille
Keywords:Cardiogenic shock, acute coronary syndrome, mechanical support, intra-aortic balloon pump, prime time.
Abstract:Cardiogenic Shock (CS) is a major challenge in current cardiology. Over the last decade,
cardiogenic shock mortality has decreased somewhat, but it still remains high, particularly when associated
with ischaemic heart disease. The challenges are numerous and include prevention, accurate diagnosis,
prompt management and effective therapies to support a failing heart and prevent multi-organ
failure. Despite improvements in the care of Acute Coronary Syndrome (ACS), it remains the most
common cause of CS. In addition to existing medical therapy, mechanical circulatory support has been
proposed for the management of ventricular failure. The intra-aortic balloon pump was amongst the first
widely used percutaneous mechanical support devices, and more recently, systems providing a higher
level of support have been developed. Although the evidence supporting their use is limited, they have
the potential to significantly reduce CS-associated mortality. In this narrative review, we summarize the
available evidence and discuss the future directions regarding percutaneous mechanical circulatory support
in patients with left ventricular dysfunction and CS complicating ACS.
