Alzheimer's Disease (AD) once considered a rare disorder emerges as a major health concern
in recent times. The disease pathogenesis is very complex and yet to be understood completely.
However, “Amyloid Cascade” is the central event in disease pathogenesis. Several proteins of the
amyloid cascade are currently being considered as potential targets for AD therapeutics discovery.
Many potential compounds are in clinical trials, but till now there is no known cure for the disease.
Recent years have witnessed remarkable research interest in the search of novel concepts in drug designing
for AD. Multi-targeted ligand design is a paradigm shift in conventional drug discovery. In
this process rather than designing ligands targeting a single receptor, novel ligands have been designed/
synthesized that can simultaneously target many pathways involved in disease pathogenesis.
Here, recent developments in computational drug designing protocols to identify multi-targeted
ligand for AD have been discussed. Therapeutic potential of different multi-potent compounds also
has been discussed briefly. Prime emphasis has been given to multi-potent ligand from natural resources.
Polyphenols are an interesting group of compounds which show efficacy against a wide
range of disease and have the property to exhibit multi-potency. Several groups attempted to identify
novel multi-potent phytochemicals for AD therapy. Multi-potency of several polyphenols or compounds
synthesized using the poly-phenolic scaffolds have been briefly discussed here. However, the
multi-targeted drug designing for AD is still in early stages, more advancement in drug designing
method/algorithm developments is urgently required to discover more efficient compounds for AD
Keywords: Alzheimer's disease, Multi-target drug designing, Phytochemicals, Structure and ligand based drug design, Amyloid
cascade, BACE1, Aβ aggregation, Antioxidant.
Rights & PermissionsPrintExport