Background: Diseases with inflammatory etiopathology have increased in incidence in recent
times. Drugs used for therapeutic management of such inflammatory diseases are relieving the
ailment but at the same time also countering serious life threatening consequences. Moreover, they are
costly and rarely available at all places. In this context, research and development on medicinal herbs
have opened a new era in the prophylactic and therapeutic management of inflammatory diseases.
Objective: To highlight the importance of anti-inflammatory medicine-synthetic drugs and natural
herbs, their constituents, mechanism of action, benefits, side effects and future prospects. The overall
aim is to provide better health services to patients regardless of their background on equality basis.
Results: Anti-inflammatory herbs have proven beneficial by combating inflammatory responses that
lead to severe abnormality in body systems. Inflammation though a protective response to infection or
injury and may result in pathological outcome when aggravated or of severe degree thus needs an early
intervention for proper resolution. Medicinal plants or their constituents are considered beneficial due
to the properties i.e., satisfactory potency, ease of availability, cheapness, less or no side effects, safer
and efficient as compared to the synthetic counterparts. These medicinal herbs contain phytoconstituents
that can prevent undesirable inflammatory processes and also posses anti-inflammatory activity.
Steroids, glycosides, phenolics, flavonoids, alkaloids, polysaccharides, terpenoids, cannabinoids, fatty
acids are common phytoconstituents present in these plants. Different mechanisms have been explored
for the anti-inflammatory action of these active ingredients. They may synergize the anti-inflammatory
pathway enzymes, factors, proteins or interfere with these in the inflammatory pathway like lipooxygenases,
cyclooxygenases, tumor necrosis factors, interleukins, prostaglandin, nitric oxide, mitogenactivated
protein, nuclear factor, etc. Considering all the above-mentioned factors, further research from
molecular to cellular level will enable a better understanding of the mechanisms. Common antiinflammatory
herbal plants are Curcuma longa, Zingiber officinale, Rosmarinus officinalis, Borago officinalis,
Urtica dioica, Uncaria tomentosa, Vaccinium myrtillus, Olea europaea and much more. They are
believed to be without side effects unlike the chemical counterparts or synthetic anti-inflammatory agents
e.g. steroids, nonsteroid anti-inflammatory drugs, and immunosuppresants used for controlling and suppressing
inflammatory crisis. A proper phytochemical, pharmacological and physiological evaluation will
enable their safe and effective use in inflammatory conditions. Many of these anti-inflammatory drugs and
herbal preparations have been patented with some under consideration.
Conclusion: Natural herbs are safe, effective and better options as anti-inflammatory agents than synthetic
ones. The phytoconstituents are as effective with the comparable mechanism of action as synthetic
molecules. Future research should focus on molecular mechanisms of different beneficial applications
of these herbal plants in various diseases. Recent patents on anti-inflammatory drugs and herbal
plants have been covered which provide insight into the current status and future prospects in this field.