Synthesis of a Novel Class of 1,3-oxathiolane Nucleoside Derivatives of T- 705 and Evaluation of Their Anti-influenza A Virus and Anti-HIV Activity

Author(s): Mingming Han, Xu Zhao, Xuedong Wu, Wei Huang, Xingzhou Li*, Fang Yu*

Journal Name: Medicinal Chemistry

Volume 14 , Issue 6 , 2018

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Graphical Abstract:


Background: T-705 (Favipiravir) is a broad spectrum antiviral agent approved for stockpiling in Japan and currently in Phase 3 testing in the United States. Against influenza, it acts as a prodrug, converted intracellularly to selectively inhibit viral RNA-dependent RNA polymerase or similar enzymes. This is regarded as a novel antiviral mechanism of action, reducing crossresistance to other existing anti-influenza drugs.

Objective: To develop new analogs, a class of 1,3-oxathiolane nucleoside derivatives of T-705 was designed and synthesized in this work.

Results: Anti-influenza activity and Anti-HIV activity of these compounds were evaluated. Compound 1a displayed activity against A H1N1 with an IC50 of 40.4 µmol/L. Compound 1b showed weak activity against HIV with a viral suppression rate of 70-80% at 30 µmol/L.

Conclusion: A class of 1,3-oxathiolane nucleoside derivatives of T-705 was designed and synthesized, and one of them was identified as a novel scaffold against viral infection.

Keywords: Nucleotide analog, favipiravi, anti-influenza, anti-HIV, 1, 3-oxathiolane nucleoside, viral enzymes.

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Article Details

Year: 2018
Published on: 12 July, 2018
Page: [595 - 603]
Pages: 9
DOI: 10.2174/1573406414666180112102225
Price: $65

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