Title:Synthesis and Cytotoxic Evaluation of Novel 3-O and 2, 3-Di-O-alkyl Derivatives of L-Ascorbic Acid
VOLUME: 15 ISSUE: 9
Author(s):Santosh Rangnath Deshmukh and Shankar Ramchandra Thopate*
Affiliation:Prof. John Barnabas Post Graduate School for Biological Studies, Department of Chemistry, Ahmednagar College, Ahmednagar, Maharashtra, 414001, Prof. John Barnabas Post Graduate School for Biological Studies, Department of Chemistry, Ahmednagar College, Ahmednagar, Maharashtra, 414001
Keywords:L-Ascorbic acid, 2, 3-di-O-alkyl derivatives of L-ascorbic acid, 3-O-alkyl derivatives of L-ascorbic acid, cytotoxicity,
vitamin, ROS.
Abstract:A series of protected and unprotected 3-O and 2, 3-di-O-alkyl derivatives of L-ascorbic acid
were synthesized and their cytotoxic activity against metastatic breast epithelial carcinoma (MCF-7)
cell line was evaluated. Cytotoxic activity evaluation indicated that compounds show moderate cytotoxic
effects on tested cell line. Some of the 2, 3-di-O-alkyl derivatives of L-ascorbic acid exhibited potent
inhibiting activity against MCF-7 cell line at micromolar concentrations. 2,3-di-O-4-chlorobenzyl-
L-ascorbic acid exhibited 4 fold more cytotoxic activity (IC50 = 34.09 μΜ ) against MCF-7 cell line
than L-ascorbic acid. 2, 3-di-O-alkyl derivatives exhibited more inhibition against MCF-7 cell line as
compared to the 3-O-alkyl derivatives of L-Ascorbic acid.
