O-Prenyl coumarins (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic
derivatives) represent a class of rarely occurring natural products. In the last two
decades, such secondary metabolites have been found to possess promising and effective
pharmacological properties, mainly in terms of anti-cancer and anti-inflammatory properties.
To date, about 160 oxyprenylated coumarins have been extracted from plants, fungi,
and bacteria. The genus Citrus has been demonstrated to be among the richest source of
the title products. The aim of this comprehensive review is to make a survey of the so far
reported literature citations about the main O-prenyl coumarins found in this genus from
phytochemical and pharmacological point of views and for which no surveys of the in so
far reported literature have been made.
Keywords: Citrus spp. Coumarins, Furanocoumarins, Oxyprenylated secondary metabolites, Phenylpropanoids,
Rutaceae, fungi, bacteria.
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