Transition Metal-Catalyzed Carboxylation of Terminal Alkynes with CO2

Author(s): Chang Qiao, Yu Cao, Liang-Nian He*.

Journal Name: Mini-Reviews in Organic Chemistry

Volume 15 , Issue 4 , 2018

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Abstract:

The coupling reaction of terminal alkynes and CO2 provides a promising way to synthesize propiolic acids. Among the existing catalytic systems, transition-metal copper and silver exhibit excellent catalytic efficiency under mild conditions probably being attributed to the activation of C-C triple bond of terminal alkynes. In this aspect, efficient strategies for activating both substrate and CO2 are often smart choices. This review summarizes the development trend of the Cu/Ag-catalyzed carboxylation reactions of terminal alkynes with CO2, and representative examples are also discussed in detail.

Keywords: Carbon dioxide, carboxylation, terminal alkyne, propiolic acids, transition metal, catalysis.

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2018
Page: [283 - 290]
Pages: 8
DOI: 10.2174/1570193X15666180101150819
Price: $65

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