Title:Transition Metal-Catalyzed Carboxylation of Terminal Alkynes with CO2
VOLUME: 15 ISSUE: 4
Author(s):Chang Qiao, Yu Cao and Liang-Nian He*
Affiliation:State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Nankai Qu, State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Nankai Qu, State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Nankai Qu
Keywords:Carbon dioxide, carboxylation, terminal alkyne, propiolic acids, transition metal, catalysis.
Abstract:The coupling reaction of terminal alkynes and CO2 provides a promising way to synthesize
propiolic acids. Among the existing catalytic systems, transition-metal copper and silver exhibit excellent
catalytic efficiency under mild conditions probably being attributed to the activation of C-C triple
bond of terminal alkynes. In this aspect, efficient strategies for activating both substrate and CO2 are often
smart choices. This review summarizes the development trend of the Cu/Ag-catalyzed carboxylation
reactions of terminal alkynes with CO2, and representative examples are also discussed in detail.
