Organocatalytic Synthesis of Spirocarbocycles

Author(s): You-Song Cheng, Shaik Anwar, Kwunmin Chen*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 15 , Issue 5 , 2018


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Abstract:

The efficient construction of C-C bonds with multiple stereocenters has been of synthetic interest to the synthetic community. This review describes the organocatalytic cascade, domino or tandem synthesis of spirocarbocycles that evolved through the use of small organic catalysts. Spirocarbocycles are frequently observed in organic compounds in nature, and the formation of spirocarbocycles is vital in contemporary organic synthesis. These reactions proceed through the combination of enamine, iminium, dienamine, and trienamine modes of activation to construct multiple C-C bonds with newly generated stereogenic centers.

Keywords: C-C bonds, organocatalytic, cascade reaction, tandem strategies, spirocarbocycles, enantioselectivity.

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Article Details

VOLUME: 15
ISSUE: 5
Year: 2018
Published on: 01 August, 2018
Page: [364 - 373]
Pages: 10
DOI: 10.2174/1570193X15666171228145726
Price: $65

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