Six-membered chalcogen, element (S, Se, N)-containing heterocycles attracted attention due
to their biological activities. This mini-review presents methods for the preparation of these heterocycles
modified by introduction of two chloromethylidene groups into their molecules. Methods for the
synthesis of bis(1,3-dihalogeno-1-propen-2-yl) chalcogenides and their oxides, and methods of their
heterocyclization with sodium sulfide and selenide, hydrazine and amine are reviewed as well as subsequent
chemical transformation of the resulting heterocycles. Due to the presence of these moieties, further
modifications of these heterocycles by the nucleophilic substitution and cross-coupling reactions
are possible and presented in the mini-review.
Keywords: Propargyl halide, sulfur dichloride, selenium dihalide, chloromethylidene group, 1, 4-dichalcogenane, N-organyl
chalcogenomorpholine, chalcogenomorpholinamine, hydrazine.
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