2-Oxazolidones are an important class of nitrogen-containing heterocyclic compounds, which
have been found to have a wide range of applications as chiral auxiliaries and chemical intermediates in
organic synthesis. Moreover, some 2-oxazolidones such as linezolid, toloxatone, and tedizolidare are
shown to have high potency as biologically active molecules and are widely used in the pharmaceutical
industry. Therefore, many efforts have been dedicated to synthesize these useful cores. Among recent
reported synthetic methods, the carboxylative cyclization reactions of inexpensive and easily available
allylic and 2,3-allenic amines with CO2 are one of the most interesting and promising synthetic procedures
from the viewpoint of developing CO2 as carbon source, since the chemical conversion of CO2 into
the value-added chemicals is one of the most important topics in green and sustainable chemistry. In
this mini review, we highlight the advances in the synthesis of 2-oxazolidone derivatives through chemical
fixation of CO2 to allylic and 2,3-allenic amines from 1987 to 2017, with special emphasis on the
mechanistic aspects of the reactions.
Keywords: Carbon dioxide, 2-oxazolidones, allylic amines, α-allenylic amines, carboxylative cyclization, green chemistry.
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