Pp. 359-372 (14)
Maria Rosangela Cunha Duarte Coelho, Georgea Gertrudes de Oliveira Mendes Cahu, Viviane Martha Santos de Morais and Ana Cecília Cavalcanti de Albuquerque
Viral hepatitis are the major cause of liver transplants in the world -
especially for hepatitis C (HCV) disorder that now affects over 185 million people in
every continent. Initially known as hepatitis non-A non-B HCV was elucidated in 1989
as an etiologic agent. Since then HCV infection acquired special importance among the
causes of liver disease particularly among HIV patients on antiretroviral therapy which
presents significant morbidity and mortality from liver disease. The natural history of
HCV is characterized by a silent evolution often the disease is diagnosed decades after
the infection and usually in advanced stage. Hepatitis C has an important impact on
global public health accounting for approximately 350,000 deaths per year.
Genetic variability, Hepatitis C virus, Treatment.
Department of Pharmaceutical Sciences, Virology Division of Laboratory of Immunopathology Keizo Asami, Federal University of Pernambuco, Brazil.