Pharmaceutical Cocrystals as an Opportunity to Modify Drug Properties: From the Idea to Application: A Review

Author(s): Agnieszka Sokal*, Edyta Pindelska

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 13 , 2018

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The properties of many drugs which have been available on the pharmaceutical market for a long time still need to be improved. Cocrystals are the solid state drug modification which can improve properties such as low solubility, stability and mechanical properties (e.g. compressibility). In this paper, examples of how to use cocrystals to modify properties of API (Active Pharmaceutical Ingredient) will be reported. Additionally, in this review, the way from an idea of the new cocrystal to drug dosage form registration will be shortly described.

Keywords: Cocrystals, stability, solubility, API, drug modification, compressibility.

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Article Details

Year: 2018
Page: [1357 - 1365]
Pages: 9
DOI: 10.2174/1381612824666171226130828
Price: $65

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PDF: 39