Background: For more than one hundred years, it has been known that some 2-
isoxazolines can be experimentally obtained by the addition of hydroxylamine or its derivatives
to α,β-unsaturated carbonyl compounds.
Methodology: General methods for the formation of 2-isoxazolines have not been formulated
Conclusion: This review will attempt to summarize the numerous published experimental
facts on the addition of hydroxylamine or its derivatives to unsaturated carbonyl compounds
and analyze these facts in the hope of proposing reaction pathways compatible
with the all the experimental data.
Keywords: Enal, enone, hydroxylamine, isoxazole, isoxazoline, isoxazolidine, oxime.
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