Background and Objective: This paper was based on a literature search of PubMed and
Scielo databases using the keywords “Flavonoids, Neuroprotection, Quercetin, Rutin, Isoquercitrin,
Alzheimer, Parkinson, Huntington” and combinations of all the words.
Method: We collected relevant publications, during the period of 2000 to 2016, emphasizing in vivo
and in vitro studies with neurological assessment of flavonol's potentials, as well as classifying studies
according to evidence levels, in order to elucidate evidence-based literature and its application on
clinical research. In addition, we highlight the importance of flavonols in modern research fields, indicating
their neuroprotective potential and use thereof as preventive and therapeutic treatment of numerous
neurodegenerative disease. Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's
disease and Huntington's disease, represent worldwide a major health problem with great financial
impact. They are multifactorial diseases, hallmarked by similar pathogenesis that covers conditions
such as oxidative stress, formation of free radicals, abnormal protein dynamics (degradation and
aggregation), mitochondrial dysfunction, lipid peroxidation and cellular death or senescence. Flavonols
are polyphenolic compounds, widely distributed in the plant kingdom and found in high concentrations
in vegetables, fruits and teas. Their neuroprotective effects are mainly related to their antioxidant,
anti-proliferative and anti-inflammatory properties.
Conclusion: It was this paper's intention to contribute with an evidence analysis of recent studies approaching
neuroprotective effects of flavonols and the potential to conduct human clinical studies.