Latest Research on Synthetics Compounds with Antileishmanial Activity

Author(s): Carlos H. Rios Martinez*, Armando A. Durant-Archibold*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 15 , Issue 4 , 2018


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Abstract:

Leishmaniasis is a neglected tropical disease caused by around 20 species of obligate intramacrophage protozoa of the genus Leishmania. This disease is an important cause of morbidity and mortality that primarily impacts the poorest populations living in tropical and sub-tropical regions of the world, but has become of concern in some developed countries. The resistance of leishmanial parasites to the drugs available and their undesirable side effects have prompted the discovery of new synthetic compounds with potent antileishmanial activity and fewer side effects that can serve as new therapeutic agents. In this article, we make a comprehensive review of the most recent advances of synthetic compounds with antileishmanial activity (from 2015 to the early 2017). Furthermore, we covered the structure- activity relationship studies that allow for optimization and selection of the most promising drugs, and the biochemical mechanisms that explain the antileishmanial activities observed.

Keywords: Antileishmanial agents, chemotherapy, leishmaniasis, Leishmania, neglected tropical diseases, synthetic compound.

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2018
Published on: 01 June, 2018
Page: [330 - 342]
Pages: 13
DOI: 10.2174/1570193X15666171218160444
Price: $65

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