Asymmetric Michael Addition Mediated by Chiral Ionic Liquids

Author(s): Yumiko Suzuki*

Journal Name: Mini-Reviews in Organic Chemistry

Volume 15 , Issue 3 , 2018

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Graphical Abstract:


Chiral ionic liquids with a focus on their applications in asymmetric Michael additions and related reactions were reviewed. The examples were classified on the basis of the mode of asymmetric induction (e.g., external induction/non-covalent interaction or internal induction/covalent bond formation), the roles in reactions (as a solvent or catalyst), and their structural features (e.g., imidazolium-based chiral cations, other chiral oniums; proline derivatives). Most of the reactions with high chiral induction are Michael addition of ketones or aldehydes to chalcones or nitrostyrenes where proline-derived chiral ionic liquids catalyze the reaction through enamine/ iminium formation. Many reports demonstrate the recyclability of ionic liquid-tagged pyrrolidines.

Keywords: Michael addition, imidazole ionic liquid, Chiral ionic liquid, asymmetric reaction, chiral solvent, catalysts.

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Article Details

Year: 2018
Published on: 19 April, 2018
Page: [236 - 245]
Pages: 10
DOI: 10.2174/1570193X15666171211165344

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PDF: 58
PRC: 2