Nattokinase: An Updated Critical Review on Challenges and Perspectives

Author(s): E. Selvarajan*, Niharika Bhatnagar

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents

Volume 15 , Issue 2 , 2017

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Graphical Abstract:


Background: Natto, a fermented soybean food, has been consumed by oriental people for more than 1000 years. Nattokinase, formerly called subtilisin NAT, is a well-studied protease of microbial origin that possesses fibrinolytic (anti-clotting) activities. Due to its strong fibrinolytic and thrombolytic activity, Nattokinase is regarded as a precious dietary supplement or nutraceutical for the oral thrombolytic therapy. Nattokinase is witnessed to be a useful enzyme for the complete removal of the vitreous and associated proliferative tissues in proliferative vitreo retinal disorders.

Conclusion: This review focuses on the native and recombinant Nattokinase from bacteria and other sources, their production, purification, immobilization and nano-immobilization studies, which aid in ameliorating their properties to suit the targeted industrial applications. Recent development in these fields are presented and discussed, and prospective developments are suggested.

Keywords: Cardiovascular disease, nano immobilization, fibrinolytic enzymes, recombinant Nattokinase, hypertention, myocardial infarction.

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Article Details

Year: 2017
Published on: 20 February, 2018
Page: [128 - 135]
Pages: 8
DOI: 10.2174/1871525716666171207153332
Price: $65

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