Title:Natural Product Formulations for the Prevention and Treatment of Alzheimer's disease: A Patent Review
VOLUME: 12 ISSUE: 1
Author(s):Rumiana Koynova* and Boris Tenchov
Affiliation:Ohio State University College of Pharmacy, Columbus, OH, Department of Medical Physics and Biophysics, Medical University-Sofia, Sofia
Keywords:Natural extract, Alzheimer's disease, dementia, neurodegeneration, neuroprotection, antioxidant activity.
Abstract:Introduction: Although considerable efforts have been made to develop effective therapeutic
agents for Alzheimer's Disease (AD), neither a consensus concerning the pathogenesis of the disease
nor a successful therapy for its treatment is yet available. The natural product chemistry brings
tremendous diversity and abundant resource for medical needs.
Objectives: The present review summarizes recent patents on natural extracts and derived drugs as
agents for the prevention and treatment of AD. It also sums up the suggested mechanisms of action of
the formulated natural remedies.
Conclusion: It is now becoming well accepted that multiple factors contribute to the progression of
AD. The pathogenesis of the disease involves amyloid-β cascade, tau hyperphosphorylation, oxidative
stress, inflammation, mitochondrial dysfunction, protein misfolding, gene mutation, etc. It has been
suggested that the multifactorial nature of AD pathogenesis requires the design of medicines with a
wide spectrum of activity. Medicinal herbs are known to consist of multiple compounds and may implicate
multiple mechanisms, thus being advantageous over the simple single-target drugs in the
treatment of complex diseases. Indeed, natural products attract increased attention. In the last decades,
they have become a major focus in the quest for AD remedies and may represent a real promise for
curing the disease.
