A Newly Synthetized Ferrocenyl Derivative Selectively Induces Apoptosis in ALL Lymphocytes through Mitochondrial Estrogen Receptors

Author(s): Marjan Aghvami, Jalal Pourahmad*, Afshin Zarghi*, Peyman Eshghi, Mohammad H. Zarei, Shabnam Farzaneh, Fatemeh Sattari

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 18 , Issue 7 , 2018

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Graphical Abstract:


Background: Estrogens, as the main female steroid hormones have multiple proven effects on reproductive and non- reproductive systems. Expression of ERα and ERβ, two dominant estrogen receptors, in peripheral blood mononuclear cells in certain B-cell malignancies and the existence of estrogens receptors on mitochondria is open to question that estrogen likely has an impact on the cancerous lymphocytes life span. Acute Lymphoblastic Leukemia (ALL) is the frequent pediatric malignity which is recurrent and hardly curable in many cases. The malignant cells are generally resistant to apoptosis caused the severe lymphocytes accumulation in the peripheral blood.

Methods: By focusing on mitochondria as a life/death center of the cell; in the current research we compared cytotoxicity effects of a new ferrocenyl derivative with raloxifene as well-known SERMs considering the apoptotic process and survival of cancerous lymphocytes.

Results: We demonstrated that both ferrocenyl derivative and raloxifene could cause mitochondrial lesion and initiate the apoptosis process by caspase activation and cytochrome c release.

Conclusion: In brief, the ferrocenyl derivative could induce estrogen-related selective apoptosis on cancerous lymphocytes by affecting mitochondrial receptors.

Keywords: Estrogen, ferrocenyl derivative, mitochondrial receptors, apoptosis, acute lymphocytic leukemia, pediatric malignity.

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Article Details

Year: 2018
Published on: 30 November, 2018
Page: [1032 - 1043]
Pages: 12
DOI: 10.2174/1871520618666171206112446
Price: $65

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