Background: Genetic changes in p53 gene contribute to breast cancer susceptibility.
Objective and Methods: A case-control study and a meta-analysis were performed to investigate the
role of p53 codon72 SNP with breast cancer susceptibility in Indian women.
Results: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total
cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated
with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation
with breast cancer occurrence.
Conclusion: The findings of our case-control study and meta-analysis suggest a significant association
between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.