Amino Acid Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-One Derivatives

Author(s): K. Mohammed Mustaque, A. Subramani, T.K. Shabeer, H. Thajudeen, V.S. Jamal Ahamed*.

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 4 , 2018

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Abstract:

A simple, convenient and facile approach for the synthesis of a series of 2,3- dihydroquinazolin-4(1H)-ones in an environmentally benign method has been developed. This method involves a direct cyclocondensation of 2-aminobenzamide with aromatic aldehydes and ketones using aspartic acid as a catalyst in water.

Keywords: Amino acid, catalyst, 2, 3-Dihydroquinazolin-4(1H)-ones, 2-aminobenzamide, ketones, water.

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2018
Page: [246 - 250]
Pages: 5
DOI: 10.2174/1570178614666171130154814
Price: $65

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