ScFv Improvement Approaches

Author(s): Peyman Bemani, Mozafar Mohammadi*, Ali Hakakian

Journal Name: Protein & Peptide Letters

Volume 25 , Issue 3 , 2018

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Abstract:

The most common recombinant antibody format is the single chain fragment variable (scFv) which it contains the complete antigen-binding domains of an intact antibody. ScFv fragments have found vast medical and non-medical applications. Several approaches have been employed to increase the affinity, avidity and structural stability related to these antibody fragments. Most approaches related to scFv improvement have been included in this review.

Keywords: scFv, avidity, affinity, scFv stability, recombinant antibody, antibody fragments.

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Article Details

VOLUME: 25
ISSUE: 3
Year: 2018
Page: [222 - 229]
Pages: 8
DOI: 10.2174/0929866525666171129225436
Price: $65

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