The most common recombinant antibody format is the single chain fragment variable
(scFv) which it contains the complete antigen-binding domains of an intact antibody. ScFv fragments
have found vast medical and non-medical applications. Several approaches have been employed
to increase the affinity, avidity and structural stability related to these antibody fragments.
Most approaches related to scFv improvement have been included in this review.
Keywords: scFv, avidity, affinity, scFv stability, recombinant antibody, antibody fragments.
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