Background: Depression is highly prevalent in End Stage Renal Disease (ESRD) and is
the most common psychiatric disorder in this population. Depression is associated with a lack of
adherence to hemodialysis (HD) treatment regimens and increased morbidity and mortality.
Methods: A descriptive secondary correlational analysis of 118 patients on chronic HD was conducted
to determine the prevalence of depression and its relationship to adherence to blood pressure
(BP) regimens (fluid adherence, HD and BP medication adherence).
Results: Approximately 80% of the sample was found to have moderate depression. Depression
was found to be significantly related to BP medication nonadherence at baseline (r = .239, p = .01
and at 12 weeks (r = .20, p = .027).
Conclusion: Given the high prevalence of depression and its association with BP medication
nonadherence, patients on chronic HD should be routinely assessed for depression and offered validated
treatment regimens. Depression is a modifiable risk factor, and interventions that address
depression in conjunction with adherence to BP regimens need to be tested in the HD population.